Since its opening in 1992, the John F. Kennedy Hyannis Museum has created a series of special exhibits and events including the following:
- November 2023 – Film Screening & Discussion – JFK: The Last Speech
- August 2023 – Summer Author Series with Dr. Douglas Brinkley
- June 2023 – USA Premiere – JFK: The Three Miles documentary
- April 2023 – Cape Cod Remembers: November 22, 1963
- April 2022 – Presidential Summers: The Kennedys on Cape Cod
- April 2021 – RFK; Ripple of Hope (return exhibit)
• The Kennedy Doll Collection, A passport to global citizenship
• JFK’s Rocking Chair, ca 1962 - June 2019 – Cape Cod Remembers JFK Jr.
- July 2018 – Creating Camelot: The Kennedy Photography of Jacques Lowe
• RFK: Ripple of Hope (original exhibit) - May 2017 – JFK at 100: Life and Legacy
- May 2016 – Rose Fitzgerald Kennedy, Mother of a President
- May 2015 – Jack and Bobby, Brothers First
- May 2014 – Cape Cod: Heart and Home of the Kennedy Family
- May 2013 – Days of Joy, Days of Sorrow. The Summer of 1963 to November 22, 1963
- June 2012 – Jackie Kennedy, Life on Cape Cod
- June 2011 – Preserving the Cape Cod Seashore
- June 2010 – Sailing with the Kennedys: Jack and Ted and the Boats They Loved
- June 2009 – The Fashion Style of Jacqueline Kennedy
- October 2008 – World Premiere of “At the Center of the World: Hyannis Port and the Presidency of JFK”
- June 2008 – Summer Sports and Recreation with the Kennedy Family 1925 – 1963
- June 2006 – The Boats of Summer
- November 2002 – Senator Edward M. Kennedy, A Special Exhibit Honoring His 70th Birthday
- July 1997 – The Kennedy Weddings
- February 1995 – The Brothers and Sisters of JFK
- October 1994 – Special Exhibit to Honor The Late Rose Fitzgerald Kennedy
- May 1994 – John F. Kennedy and Jacqueline Kennedy Onassis, A Special Exhibit